PSMD1(26S蛋白酶非ATPase调节亚基1),也被称为26S蛋白酶调节亚基Rpn2(系统命名法),是一种在人体中由PSMD1基因编码的蛋白质。该蛋白是19S蛋白酶复合物完整组装中的19个必需亚基之一。
PSMD1基因编码的蛋白是19S蛋白酶复合物完整组装中的19个必需亚基之一。19S蛋白酶复合物是一个重要的蛋白质降解机制,其中26S蛋白酶是其核心。该复合物在细胞内参与对异常、老化或已损坏蛋白的降解和清除。这一过程对于维持细胞功能和健康至关重要。
PSMD1的功能是作为非ATPase调节亚基,与其他蛋白亚基一起形成19S蛋白酶复合物的结构基础。它通过与其他亚基相互作用,参与调节蛋白酶的活性和底物的选择性识别。19S蛋白酶复合物通过其ATPase活性驱动底物的去泡作用,将底物引导到核心蛋白酶的降解腔室中。
PSMD1基因与一些疾病有关,包括囊性纤维化和巴代特-比德尔综合征。这些疾病可能与蛋白酶复合物的功能异常或降解通路的紊乱有关。
PSMD1基因编码的蛋白质参与多种信号转导和细胞生理过程。它与调节激活的PAK-2p34通过蛋白酶介导的降解和前复制复合物的组装等途径相关。
总之,PSMD1是一个关键的蛋白质亚基,参与构建19S蛋白酶复合物,该复合物在细胞内负责蛋白质降解和清除。PSMD1的异常功能可能与一些疾病的发生和发展有关。对于深入理解细胞代谢和蛋白质调控机制,以及发展相关疾病的治疗策略,进一步研究PSMD1的功能和调控机制具有重要意义。
参考来源:
1. PSMD1 – Wikipedia ([https://en.wikipedia.org/wiki/PSMD1) ↗](https://en.wikipedia.org/wiki/PSMD1))
2. NCBI Gene: PSMD1 ([https://www.ncbi.nlm.nih.gov/gene/5707) ↗](https://www.ncbi.nlm.nih.gov/gene/5707))
折疊內容
PSMD1PSMD126S proteasome non-ATPase regulatory subunit 1, also as known as 26S Proteasome Regulatory Subunit Rpn2 (systematic nomenclature), is a protein that in humans is encoded by the PSMD1 gene. This protein is one of the 19 essential subunits that contributes to the complete assembly of 19S proteasome complex.https://en.wikipedia.org › wiki › PSMD1PSMD1 – Wikipedia (Proteasome 26S Subunit, Non-ATPase 1) is a Protein Coding gene. Diseases associated with PSMD1 include Cystic Fibrosis and Bardet-Biedl Syndrome. Among its related pathways are Regulation of activated PAK-2p34 by proteasome mediated degradation and Assembly of the pre-replicative complex.
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Read More: What is 26S proteasome non ATPase regulatory subunit 1?